Demi Moore gives a career-best performance as Elisabeth Sparkle, a former A-lister "past her prime" and fired from her fitness TV show by the repellent studio head (Dennis Quaid). She is drawn to the opportunity presented by a mysterious new drug: THE SUBSTANCE. All it takes is one injection and she is reborn – temporarily – as the twentysomething Sue (Margaret Qualley). The only rule? You are one, and time needs to be split: one week in one body, one week in the other. What could go wrong?
